Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis
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چکیده
منابع مشابه
Efficacy of an Abbreviated Induction Regimen of Amphotericin B Deoxycholate for Cryptococcal Meningoencephalitis: 3 Days of Therapy Is Equivalent to 14 Days
UNLABELLED Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care but may not be suitable for resource-poor settings. We investigated the efficacy of conventional and abbreviated regimens of dAmB for cryptococcal meningoencephalitis in both murine and rabbit models of cryptoc...
متن کاملLow CD4 count plus coma predicts cryptococcal meningitis in Tanzania
BACKGROUND Largely due to the lack of diagnostic reagents, the prevalence and clinical presentation of cryptococcal meningitis in Tanzania is poorly understood. This in turn is limiting the impact of increased fluconazole availability. METHODS We evaluated a cohort of 149 consecutive HIV-infected adult inpatients presenting with headache or altered mental status for clinical features, CD4 cou...
متن کاملOral versus intravenous flucytosine in patients with human immunodeficiency virus-associated cryptococcal meningitis.
In a randomized controlled trial of amphotericin B-based therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis in Thailand, we also compared the mycological efficacy, toxicity, and pharmacokinetics of oral versus intravenous flucytosine at 100 mg/kg of body weight/day for the initial 2 weeks. Half of 32 patients assigned to the two arms containing flucytosine were ra...
متن کاملCryptococcal meningitis in Durban, South Africa: a comparison of clinical features, laboratory findings, and outcome for human immunodeficiency virus (HIV)-positive and HIV-negative patients.
We retrospectively compared the clinical manifestations, laboratory features, and outcome of cryptococcal meningitis in 44 human immunodeficiency virus (HIV)-positive and 21 HIV-negative patients in Durban, South Africa, and contrasted our findings with those in the developed world. Cryptococcal meningitis was the initial AIDS-defining illness in 84% of patients. Headache, fever, convulsions, n...
متن کاملCryptococcal Meningitis and Pulmonary Cryptococcosis in a Non-hiv Infected Patient
Correspondence: Dr Amit Agrawal Associate Professor of Neurosurgery, Department of Neurosurgery, K.S. Hegde Medical Academy, Nityananda Nagar, Mangalore-575108, Karnataka,India. E-mail: [email protected] INTRODUCTION Cryptococcosis has dramatically increased in frequency as a result of the pandemic of human immunodeficiency virus (HIV) infection and an enlarging population of other immuno...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017